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pentobarbital will minimize the extent or impact of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Pitolisant exposure is decreased by 50% if coadministered with potent CYP3A4 inducers.pentobarbital will minimize the extent or influence of exemestane by impacting hepatic/intestinal enzy